Antagene Histiocytic Sarcoma Risk Test subsidized by the BMDCA - Entry deadline April 16th

Wednesday, April 30, 9:00am-1:00pm, All Star Lobby Office

IMPORTANT: Participants MUST DOWNLOAD, COMPLETE & SIGN the following REQUIRED DOCUMENTS (links provided in Description below) and bring completed paperwork to the clinic:

AGREEMENT* (only one per person)

SAMPLING CERTIFICATE* (one per dog tested)

FOUR-GENERATION HORIZONTAL PEDIGREE**

*Available in the Description below, along with FAQ and Home Collection Instructions

**Download from the Berner-Garde database https://bernergarde.org/DB/Default

Direct all questions to Julie Jackson at [email protected]

NOTE: If your dog has either been diagnosed with histiocytic sarcoma* or over 10 years of age**, choose corresponding free research sample from the drop down menu; *If your dog is affected, please provide diagnostic notes or pathology results from your vet. **To participate, contact Julie Jackson for details

OPTIONAL HEALTH STUDY FOR DOGS AGE 6 & OLDER AT TIME OF TEST: Study on early cancer screening for Histiocytic Sarcoma. This research is led by Dr. Benoit Hedan, Dog Genetics Team, IGDR, University of Rennes, France. Dogs 6 years or older, and cancer free are needed. Blood draw will occur in conjunction with the Histiocytic Sarcoma Risk Test Clinic. (Unfortunately, participation is limited to dogs in attendance.) This blood draw is supported by the BMDCA at no charge to participants. For information on the research, click here to visit Cani-DNA OncoDiagnostic | Institute Genetics & Development of Rennes. Questions? Contact Julie Jackson at [email protected] or cell (206) 930-3290.

Histiocytic Sarcoma Genetic Risk Test

From $50

Part Number: BMDCA-HRT

Availability: In Stock

Options *

Participation *

In-Person (blood drawn at specialty clinic) Remote (blood drawn by own vet; hand-delivered on day of clinic)

Registered Name of Dog *

Required (no titles):

Call Name *

Required:

Date of Birth (MM/DD/YY) *

Required:

I am interesting in participating in the optional health study for early cancer detection

For Dogs Aged Six & Older

Sex (required) *

Male Female

Identification *

Required (Chip or Tattoo No.):

Berner-Garde ID# *

Insert:

Your Kennel Name

(Insert n/a if not applicable):

HSIMS Access (choose one) *

Self (authorized user on the HSIMS test mating website) Other (HSIMS user access granted to breeder/other)

Provide name & email in Comments.

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Description

REQUIRED FORMS

Memorandum of Agreement/Terms & Conditions (Only one Agreement required per owner/breeder participating in clinic)

Sampling Certificate

4 Generation Pedigree (download from the Berner-Garde database for each dog being tested https://bernergarde.org/DB/Default)

CLINIC & RISK TEST INFORMATION

Frequently Asked Questions (FAQ )

Home Instructions (for samples hand-delivered to the in-person clinic)

Overview of Antagene's HSIMS Mate Selection Tool

Direct all questions not addressed in the Home Instructions or FAQ to Julie Jackson at [email protected]

IMPORTANT NOTE: The individual listed as "Owner" will receive results by email AND will be the only authorized user* for the tested dog on the HSIMS test mating website. If you prefer your Breeder/Co-Owner receive the results/breeder tool access, list that individual's name and email in the Comment section. *ONLY ONE USER PER DOG.

The ANTAGENE Laboratory, in collaboration with the CNRS Canine Genetics Team, has agreed to partner with the BMDCA to offer a clinic for the Histiocytic Sarcoma Risk Test at the BMDCA National Specialty. Normal price per dog is ~$120USD but BMDCA is pleased to announce special subsidized pricing for this clinic, with rates as low as $50! (See Options)

For over ten years, the Canine Genetics team of the CNRS in Rennes (France) and their international collaborators have been conducting genetic studies on Histiocytic Sarcoma in the Bernese Mountain Dog. These studies allowed them to locate regions of the genome implicated in this disease. The analysis of a large number of samples (more than 2000 Bernese Mountain Dogs) from affected dogs as well as old healthy dogs has enabled researchers to identify genetic markers associated with risk of developing and transmitting this cancer. Studies continue to investigate these genomic regions. Statistical analysis of these genetic markers has been used to produce a genetic index. This index can help breeders in the selection of breeding stock and matings. It is not, however, a prediction of the occurrence of the disease. This test is only a probability test, based on information from a population of 2,000 French Bernese Mountain Dogs; validated on European and American populations (over 900 Bernese Mountain Dogs in the U.S.)

The test for Histiocytic Sarcoma is not an endpoint but a continuation of the research on Histiocytic Sarcoma. The test will be optimized and refined with advanced research. For this your participation is essential.

NOTE: DNA extracted from your dog's sample may be used for research in canine genetics.

Histiocytic Sarcoma Genetic Risk Test

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